This clue appeared in the NYT Crossword on Saturday, December 27, 2025 (27 Down). The answer is hidden below until you want it. Saturday puzzles are the hardest of the week and themeless, so clues are often deliberately misleading.
Answer length: 4 squares
First letter
S _ _ _
First and last letters
S _ _ S
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About the answer
SALS as a word: (pathology) Abbreviation of sporadic amyotrophic lateral sclerosis; (pathology) Alternative form of sALS; Abbreviation of sporadic amyotrophic lateral sclerosis.
SALS has been an answer 3 times in the NYT Crossword and Mini since December 27, 2025.
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