This clue appeared in the NYT Crossword on Sunday, January 4, 2026 (10 Down). The answer is hidden below until you want it. Sunday puzzles are large (21 by 21) and themed, about as hard as a Wednesday or Thursday.
Answer length: 6 squares
First letter
I _ _ _ _ _
First and last letters
I _ _ _ _ R
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About the answer
ISOMER as a word: (physical chemistry) Any of two or more compounds with the same molecular formula but with different structure; (nuclear physics) Any of two or more atomic nuclei with the same mass number and atomic number but with different radioactive properties.
ISOMER has been an answer 2 times in the NYT Crossword and Mini since January 4, 2026.
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