This clue appeared in the NYT Crossword on Tuesday, April 21, 2026 (64 Across). The answer is hidden below until you want it. Tuesday puzzles are a step up from Monday but still mostly straightforward.
Answer length: 6 squares
First letter
I _ _ _ _ _
First and last letters
I _ _ _ _ R
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About the answer
ISOMER as a word: (physical chemistry) Any of two or more compounds with the same molecular formula but with different structure; (nuclear physics) Any of two or more atomic nuclei with the same mass number and atomic number but with different radioactive properties.
ISOMER has been an answer 2 times in the NYT Crossword and Mini since January 4, 2026.
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