This clue appeared in the Mini Crossword on Saturday, November 22, 2025 (4 Down). The answer is hidden below until you want it.
Answer length: 7 squares
First letter
O _ _ _ _ _ _
First and last letters
O _ _ _ _ _ S
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About the answer
OPIATES as a word: (pharmacology) A drug, hormone or other substance derived from or related to opium; (pharmacology) Relating to, resembling, or containing opium.
OPIATES has been an answer once in the NYT Crossword and Mini puzzles we have on file, which go back to October 23, 2025.
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