This clue appeared in the NYT Crossword on Thursday, February 26, 2026 (17 Across). The answer is hidden below until you want it. Thursday puzzles often have a trick, such as a rebus (several letters in one square) or answers that bend the rules.
How to read this clue
"E.g." means the clue gives an example, and the answer names the group it belongs to.
Answer length: 6 squares
First letter
O _ _ _ _ _
First and last letters
O _ _ _ _ E
Show the answer
About the answer
OPIATE as a word: (pharmacology) A drug, hormone or other substance derived from or related to opium; (pharmacology) Relating to, resembling, or containing opium.
OPIATE has been an answer 2 times in the NYT Crossword and Mini since February 26, 2026.
Other clues with the same answer
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